NanoResveratrol™

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15 June 2009

Life Enhancement

USA

Food and Beverage

Supplements

"Resveratrol is certainly the powerhouse of what nutritional supplements can offer . . . with a mind-boggling cornucopia of across-the-board, high-end benefits to improve health dramatically. Yet these remarkable benefits have been somewhat elusive owing to extremely limited bioavailability when resveratrol is taken orally. Not only has it been difficult to enhance its solubility and increase absorption—owing to acids and digestive enzymes in the stomach, intestines, and liver—but it has also been a challenge to inhibit resveratrol’s metabolism to other substances and sustain high plasma levels. Moreover, delivering them in adequate amounts to the most important tissue targets has been virtually unachievable. Until now. Nanospheres are about to change all that, because they embrace and embody state-of-the-art nutrient-delivery technology that can defeat the pitfalls of the oral delivery route. A product of nanotechnology, as the name implies, nanospheres are very small particles, measured in nanometers (nm), or billionths of a meter. These particles, with dimensions in the range from 1 to 1000 nm, are now burgeoning into the field of drug- and nutrient-delivery systems with diameters as small as 50 nm or even lower. The ones starting to show particularly great efficacy are made of natural lipids, in which lipophilic compounds, such as resveratrol and curcuminoids, can readily dissolve. Their purpose is to improve the bioavailability of such compounds by exploiting their own special size range and unique properties. Long under development, nanospheres typically consist of a central, spherical core of a natural, plant-based lipid, such as a solid triglyceride (fat), encased by a shell consisting of a natural phospholipid, such as phosphatidylcholine. The latter acts as an emulsifying agent during the production process; thereafter it serves a protective function, its chemical properties playing a vital role in stabilizing the nanospheres in their aqueous environment."

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'All of my adult life I have suffered from very thick skinned, callused feet for which I have tried lotions, pumice stones, foot scrubs … you name it. As much as I tried, I just could not soften my feet. Worse, my feet were scaly and would crack, even to the point of bleeding several times throughout the year. For this, I would bind them with surgical tape. '' ''Then someone suggested that I try resveratrol topically, because resveratrol has antifungal properties. Since I couldn’t find a topical resveratrol, I made my own with resveratrol powder dissolved in MCT oil. It made a noticeable difference, but then on a lark, I acquired a bottle of your nanosphere resveratrol because you claim that it has increased bioavailability. Without a doubt, it does! '' ''It’s hard to believe, but my feet have softened, remarkably so, and today they are baby soft. It’s been nearly two years now and there has been no more cracking!''

'Despite resveratrol’s ability to remodel Aβ in vitro, Mount Sinai’s Pasinetti dismisses resveratrol as a therapeutic agent because of what he believes to be its limited bioavailability. And there is not enough of a concentration of resveratrol in red wine to produce the desired biological effect. There is dismissal from Tessier too, stating that there is no evidence that resveratrol can cross the blood-brain barrier. Yet other new research indicates that certain nanoparticles, created by the nanoprecipitation method, can transport resveratrol across the brain’s blood-brain barrier.11 These nanoparticles were found to possess a particle size of 80-110 nm, suitable for blood brain barrier permeation. They also demonstrated a sustained drug release behavior. For this reason, nanoparticles may be useful for delivering resveratrol and thus treating neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases.'' ''Nanoparticles are another example of how structure and function are integral. When their structure is well designed for the task of crossing the blood-brain barrier, they serve to function as carriers for a group of small molecules that been shown to break up or prevent harmful Aβ aggregates, including resveratrol, which can remodel the brain and perhaps restore its function to what is proper. The architect Frank Lloyd Wright would tip his pork-pie hat to that.'' Will Block (2012)

Nanocellulose

775mg

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Health applications

Suspended in liquid

Category 2 (Verified claim)