NanoCurcuminoids™

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15 June 2009

Life Enhancement

USA

Food and Beverage

Supplements

"Curcuminoids—the most biologically active compounds in turmeric—have been highly praised for their across-the-board, high-end potential to dramatically improve health. Yet these remarkable benefits have been somewhat elusive, owing to extremely limited bioavailability when curcuminoids are taken orally. Not only has it been difficult to enhance their solubility and increase absorption—owing to acids and digestive enzymes in the stomach, intestinal lumen, intestinal wall, and liver—but it has also been a challenge to prevent their metabolism to other substances while sustaining high plasma levels. Moreover, delivering them in adequate amounts to the most important tissue targets has been virtually unachievable. Until now. Solid-lipid nanospheres (SLNs) are about to change all that, because they embrace and embody state-of-the-art nutrient-delivery technology that can defeat the pitfalls of the oral delivery route. SLNs, a product of nanotechnology, as the name implies, are very small particles, measured in billionths of a meter. These nanoparticles, with dimensions in the range from 1 to 1000 nanometers (nm), are now burgeoning into the field of drug- and nutrient-delivery systems as nanospheres, with diameters as small as 50 nm or even lower. The ones starting to show particularly great efficacy are made of natural lipids, in which lipophilic compounds, such as curcuminoids, can readily dissolve. Their purpose is to improve the bioavailability of such compounds by exploiting their own special size range and unique properties."

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'I read online nano curcuminoids might help cirrhosis of the liver. This was research done in India I think. The NanoBioSphere delivery system is interesting and seems effective. I do like this product, but I also like Life Extension Super Bio-Curcumin and Eclectic Turmeric. I think I'll try combining NanoCurcuminoids with Eclectic Institute Turmeric next time. I also always take ginger with turmeric.''

'Curcumin, a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequently, minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents like curcumin dispersible in aqueous media, thus circumventing the pitfalls of poor solubility.'' ''Nanocurcumin provides an opportunity to expand the clinical repertoire of this efficacious agent by enabling ready aqueous dispersion. Future studies utilizing nanocurcumin are warranted in pre-clinical in vivo models of cancer and other diseases that might benefit from the effects of curcumin.'' Savita Bish, Georg Feldmann, Sheetal Soni, Rajani Ravi, Collins Karikar, Amarnath Maitra, Anirban Maitra (2007)

Nanocellulose

595mg

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Health applications

Suspended in liquid

Category 2 (Verified claim)