Pulmonary Toxicity of Diesel Exhaust Particles

Project Information

Principal Investigator	Jane Ma
Institution	National Institute for Occupational Safety and Health
Project URL	View
Relevance to Implications	High
Class of Nanomaterial	Incidental Nanomaterials
Impact Sector	Human Health
Broad Research Categories	Hazard Characterization
NNI identifier

Funding Information

Country	USA
Anticipated Total Funding	n/a
Annual Funding	n/a
Funding Source	NIOSH
Funding Mechanism	Intramural
Funding Sector	Government
Start Year	2004
Anticipated End Year	2004

Abstract/Summary

The objective of this project is to characterize the role of generation of reactive oxygen species in pulmonary toxicity resulting from exposure to diesel exhaust particles. Specifically, the role of reactive oxygen species in the induction or degradation of pulmonary P450 enzymes and the resulting effects on xenobiotic metabolism and metabolic-dependent mutagenicity will be evaluated. Sources of reactive oxidant production in response to diesel exhaust particle exposure, such as reactive oxygen species production from P450 enzymes or nitric oxide production from nitric oxide synthase, will be characterized.