Nanoparticles: Dosimetry and Risk Assessment

Project Information

Principal Investigator	Eileen Kuempel
Institution	National Institute for Occupational Safety and Health
Project URL	View
Relevance to Implications	High
Class of Nanomaterial	Engineered Nanomaterials
Impact Sector	Human Health
Broad Research Categories	Hazard Safety Risk Assessment
NNI identifier

Funding Information

Country	USA
Anticipated Total Funding	n/a
Annual Funding	n/a
Funding Source	NIOSH
Funding Mechanism	Intramural
Funding Sector	Government
Start Year	2004
Anticipated End Year	2009

Abstract/Summary

In this project, a current rat lunch dosimetry model will be extended to include biologically relevant paths for the transport of nanoparticles to the blood and other organs as well as excretion. Data from the literature will be used to calibrate this model, and data from new studies at NIOSH and elsewhere will be used to validate the model. The model will be extrapolated to humans using human data where available (e.g., physiological parameters), and biologically based approaches to interspecies extrapolation will be applied to estimate from the rat model the parameter values not available in humans. These lung dosimetry models will be used in conjunction with rodent dose-response data to estimate risk of adverse health effects in workers and working lifetime exposure concentrations that are not expected to cause adverse health effects.