Dynamics, distribution and photochemistry of quantum dots in blood vessels

Project Information

Principal Investigator	David Cramb
Institution	University of Calgary
Project URL	View
Relevance to Implications	High
Class of Nanomaterial	Engineered Nanomaterials
Impact Sector	Human Health
Broad Research Categories	Hazard Generation, Dispersion, Transformation etc. Characterization
NNI identifier

Funding Information

Country	Canada
Anticipated Total Funding	$86,883.00
Annual Funding	$43,441.50
Funding Source	NSERC
Funding Mechanism	Extramural
Funding Sector	Government
Start Year	2005
Anticipated End Year	2007

Abstract/Summary

There is significant need for data that will help us to predict the distribution of nanoparticles in the blood stream. We propose to develop a model system for blood vessels in which to examine the distribution and dynamics of quantum dot nanoparticles. We will determine the affect of quantum dot size and surface chemistry on their localization and transportation dynamics in the blood vessel system of a chick embryo’s chorioallantoic membrane (CAM). The CAM is a membrane that functions as a chicken embryos lungs during early development. The CAM has a blood vessel system that will be used as a test bed for quantum dot behavior in more complex living systems. We will create an information matrix that will allow the prediction of quantum behavior in the blood vessels of higher organisms.