Mechanisms of cellular interactions of functionalized rosette nanotubes
Project Information
| Principal Investigator | Baljit Singh |
| Institution | University of Saskatchewan |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Hazard Characterization |
| NNI identifier |
Funding Information
| Country | Canada |
| Anticipated Total Funding | $86,883.00 |
| Annual Funding | $43,441.50 |
| Funding Source | NSERC |
| Funding Mechanism | Extramural |
| Funding Sector | Government |
| Start Year | 2005 |
| Anticipated End Year | 2007 |
Abstract/Summary
Nanotechnology, the science of very small particles, is expected to alter the way we live our lives. Once realized, the potential of nanotechnology will enhance existing products and create new smart products. Before this all happens, many fundamental questions and issues need to be addressed. To develop a better relationship of nanotubes with the cells, it is critical to understand how cells interact with nanotubes. We have developed rosette nanotubes (RN), which are different than the commonly used single-walled carbon nanotubes. We propose to tag radioactively-labeled RN with a short peptide (RGD) conjugated to a fluorescent molecule. The RGD peptide plays important role in the function of defense cells such as neutrophils in our bodies. Therefore, we will examine how RGD-RN interact with the cells in vitro and in vivo. Because RGD interact with a sticky protein called integrin beta-3, we will focus on the interactions between RGD-RN and the integrin. These studies will clarify fundamental processes of interaction of RN with the cells. Eventually, it is expected that we will find ways to use RN as smart weapons for precise delivery of drugs to treat diseases such as pneumonia.
