Neurotoxicity after Pulmonary Exposure to Welding Fumes Containing Manganese

Project Information

Principal Investigator	James Antonini
Institution	National Institute for Occupational Safety and Health
Project URL	View
Relevance to Implications	High
Class of Nanomaterial	Incidental Nanomaterials
Impact Sector	Safety
Broad Research Categories	Hazard Response Generation, Dispersion, Transformation etc.
NNI identifier

Funding Information

Country	USA
Anticipated Total Funding	n/a
Annual Funding	n/a
Funding Source	NIOSH
Funding Mechanism	Intramural
Funding Sector	Government
Start Year	2006
Anticipated End Year	2010

Abstract/Summary

Characterized the physical and chemical properties of generated welding aerosol. Compared the pulmonary, inflammatory, and immune responses after exposure to stainless steel and mild steel welding fumes. Designed and constructed a robotic welding fume generator and inhalation exposure system for laboratory animals. Initiated animal inhalation toxicity studies. Evaluated the translocation of welding fume metals from the lungs to other organ systems (e.g., central nervous system and cardiovascular system). Evaluated the potential neurotoxic effects in animals after inhalation of welding fume is being evaluated.