In vitro reactivity of fine and ultrafine particles
Project Information
| Principal Investigator | Jean-Jacques Sauvain |
| Institution | Research group "Particles and Health", Institute for Work and Health, (Institut universitaire romand de Santé au Travail), Université Lausanne + Université Genève, Switzerland |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Generic |
| Impact Sector | Human Health |
| Broad Research Categories |
Hazard
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| NNI identifier | |
Funding Information
| Country | Switzerland |
| Anticipated Total Funding | $327,365.00 |
| Annual Funding | $109,121.67 |
| Funding Source | French AFSSET and Institut universitaire romand de Santé au Travail |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2007 |
| Anticipated End Year | 2010 |
Abstract/Summary
Toxicity of particulates may be due to the reactivity of their surface when entering in contact with cells. Among other, their potential to generate reactive oxygen species seems to be very important. This work intends to use a simple method in order to determine the ability of some particles (ultrafine TiO2, crocidolite, diesel SRM 1650 and particles from real occupation situations) to catalyse the oxygen reduction by ascorbic acid. The results obtained indicated that: It is possible to detect such reaction with simple equipment (specific oxygen electrode) In the experimental conditions, diesel SRM 1650 reacts about 10 times faster than crocidolite and that ultrafine TiO2 didnt showed any reactivity. Particles sampled in a bus depot indicated a very high reactivity. Heavy metals (Fe, Cu) could be potential important elements to explain this reactivity. Experimental improvement has to be done mainly for getting a particulate suspension without artefacts.
