Multidisciplinary University Research Initiative: Effects of Nanoscale Materials on Biological Systems: Relationship between Physiochemical Properties and Toxicological Properties
Project Information
| Principal Investigator | Günter Oberdörster |
| Institution | University of Rochester |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Hazard Safety Characterization |
| NNI identifier | b1-1 |
Funding Information
| Country | USA |
| Anticipated Total Funding | $5,500,000.00 |
| Annual Funding | $1,100,000.00 |
| Funding Source | DOD |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2004 |
| Anticipated End Year | 2009 |
Abstract/Summary
This research tests the hypothesis that physicochemical properties of NP determine their interactions with cells with respect to their uptake, translocation, interference with cellular functions and disposition within cellular substructures and tissues. The ultimate goal is to develop and test computational models that can forecast a nanostructure-induced cellular response. This goal will be achieved with a multidisciplinary team approach involving scientists from three universities and ten different departments.
The scope of the research includes the use of selected nano-sized particles of metals and metal oxides with well-defined physical and chemical properties. It will demonstrate how size (3-100 nm), surface properties, composition and crystallinity influence cellular uptake and disposition of these nanomaterials and their ability to elicit inhibitory and/or stimulatory responses at the subcellular, cellular and whole tissue levels.
