Dermal Effects of Nanoparticles
Project Information
| Principal Investigator | Anna Shvedova |
| Institution | National Institute for Occupational Safety and Health |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Exposure Hazard |
| NNI identifier | b4-9 |
Funding Information
| Country | USA |
| Anticipated Total Funding | $700,000.00 |
| Annual Funding | $233,333.33 |
| Funding Source | NIOSH |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2004 |
| Anticipated End Year | 2007 |
Abstract/Summary
Nanoparticles are new materials of emerging technological importance in different industries. Because dermal exposure is likely in a number of occupational settings, it is very important to assess whether nanoparticles could cause adverse effects to skin. The hypothesis is that nanoparticles are toxic to the skin and the toxicity is dependent on their penetration to skin, induction of oxidative stress, and content of transition metals. Because inflammation provides a redox environment in which transition metals can fully realize their pro-oxidant potential, a combination of inflammatory response with metal oxide particles, or iron-containing SWCNT will synergistically enhance damage to cells and tissue. Results obtained from these studies provide critical knowledge about mechanisms of dermal toxicity of nanoscale materials and will be used by regulatory agencies (OSHA and EPA) and industry to address strategies for assurance of healthful work practices and safe environments.
(Project budget is an estimate only, based on available data)
