Systematic Microvascular Dysfunction Effects of Ultrafine Versus Fine Particles
Project Information
| Principal Investigator | Vincent Castranova |
| Institution | National Institute for Occupational Safety and Health |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Exposure Hazard |
| NNI identifier | b5-37 |
Funding Information
| Country | USA |
| Anticipated Total Funding | $600,000.00 |
| Annual Funding | $200,000.00 |
| Funding Source | NIOSH |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2004 |
| Anticipated End Year | 2007 |
Abstract/Summary
Nanotechnology is one of the fastest growing emerging technologies in the United States and across the world. Defined as the manipulation of matter at near-atomic scales to produce new materials, structures, and devices with unique properties, nanotechnology has potential applications for integrated sensors, semiconductors, medical imaging, drug delivery systems, structural materials, sunscreens, cosmetics, and coatings. The NIOSH Nanotechnology Research Center identifies elucidation of cardiovascular effects of airborne nanoparticles as a critical issue. This study will compare the effects of inhalation exposure to fine vs. ultrafine TiO2 and monitor pulmonary effects and alterations in systemic microvascular function. The role of oxidant stress at the microvessels will be explored. Data will be disseminated by presentation at scientific meeting, publications in journals, summaries in the NIOSH e-News and Nanotech Web page, and meeting with partners.
(Project budget is an estimate only, based on available data)
