Pulmonary Toxicity of Carbon Nanotube Particles
Project Information
| Principal Investigator | Anna Shvedova |
| Institution | National Institute for Occupational Safety and Health |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Hazard Risk Assessment |
| NNI identifier | b5-36 |
Funding Information
| Country | USA |
| Anticipated Total Funding | $900,000.00 |
| Annual Funding | $300,000.00 |
| Funding Source | NIOSH |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2004 |
| Anticipated End Year | 2007 |
Abstract/Summary
This project will evaluate mechanisms of pulmonary toxicity in response to in vitro or in vivo exposure to carbon nanotubes. Specific aims are: 1) to study mechanisms of cytotoxicity of carbon nanotubes in culture systems of bronchial epithelial cells, macrophages and alveolar type II cells; 2) to determine the effect of pharyngeal aspiration of carbon nanotubes in a mouse model - determine dose-response and time course; 3) to develop a generation system for carbon nanotube aerosols; 4) to conduct inhalation exposure to aerosolized carbon nanotube particles and monitor the pulmonary response in a mouse model.
(Project budget is an estimate only, based on available data)
